Protein L is a bacterial protein that binds to the kappa light chains of IgG-type antibodies. However, it does not bind to lambda light chains. As such, Protein L gold conjugates allow for convenient and quick conjugation of antibodies containing a kappa chain to the gold surface, which can then be utilized further downstream. An advantage of Protein L over Protein A and Protein G is that it is capable of binding to single-chain antibody fragments (scFv) and Fab fragments, allowing for finer optimization.
Cytodiagnostics Protein L conjugated gold nanoparticles are suitable for use in immunoblotting, light microscopy, electron microscopy applications, and other procedures for detection of antibody-labelled samples.