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Silver Nanoparticle Product Selection Guide

Choose Silver Nanoparticle Products Based on Application


Application Silver Nanoparticle
Size Range
Surface Chemistry Benefits Related Documents
Protein Conjugation 10nm-100nm standard (citrate) Quick Conjugation of proteins to silver nanoparticles
NHS Covalent conjugation, increased stability, less non-specific protein binding. Conjugation of proteins to NHS-activated silver nanoparticles
Carboxyl Covalent conjugation, increased stability, less non-specific protein binding. Conjugation of proteins to silver nanoparticles



Streptavidin Can be used with any biotinylated ligand, ideal for high-throughput screenings. -
Modification with thiolated ligands 
(PEG-SH etc.)
10nm-100nm standard (citrate) Classic starting material, no additional stabilizers added -





Oligonucleotide Conjugation 10nm-20nm standard (citrate) Ideal for conjugation of thiolated oligonucleotides -
10nm-100nm Carboxyl Ideal for conjugation of amine functionalized oligonucleotides and particles above 20nm in diameter. -
Immuno-dot blot/Western blot 10nm-30nm Protein conjugated silver nanoparticles (antibodies, streptavidin etc) Colorimetric straightforward detection (no equipment required)
Generates a permanent label
Immunoblotting protocol for noble metal protein conjugates
Immunohistochemistry (TEM) 10nm-40nm Protein conjugated silver nanoparticles (antibodies, streptavidin etc) High contrast label -




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Cellular Uptake 30nm-60nm Standard (citrate)
Non-specific cellular uptake
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Darkfield Microscopy 50nm-100nm Silver conjugates - -
Lateral Flow/Dip-Stick Assays 30nm-80nm Standard (citrate) Allows for development of rapid testing kit, point of care assays Lateral flow immunoassays
NHS
Carboxyl

Streptavidin
Protein A

Tumor Targeting 30nm-80nm methoxy-PEG Allows for passive targeting of certain tumors in vivo
Inert material with low non-specific protein binding in serum
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Light Microscopy 10nm Silver secondary antibody conjugates Ability to label tissue sections for both light and electron microscopy. 
Alternative to peroxidase and PAP based stains.
Sensitivity can be enhanced with silver enhancement techniques
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ELISA 10nm-30nm Silver antibody conjugates Straightforward colorimetric detection -